AJU GLOBAL LIMITED.: Coartem(reg) (artemether-lumefantrine) most effective malaria treatment in areas of high resistance to conventional anti-malarials

Friday 8 January 2016

Coartem(reg) (artemether-lumefantrine) most effective malaria treatment in areas of high resistance to conventional anti-malarials

UNICAF

A new study published in The Lancet suggests that the combination of artemether and lumefantrine, available from Novartis under the brand name Coartem, is the most effective available treatment for malaria in children in areas of Africa where resistance to conventional anti-malarial drugs is high. Developed and produced by Novartis and its Chinese partners, Coartem is currently the only fixed-dose artemisinin-based combination therapy pre-qualified by the World Health Organization (WHO) for procurement by United Nations agencies.

Recently, the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria approved a grant of USD 170 million to seven African nations for the procurement of Coartem over the next two years.

"These new clinical data confirm that Coartem is the current gold standard to treat malaria in areas of high resistance to conventional anti-malarials and is as such a life-saving drug," said Dr. Daniel Vasella, Chairman and CEO of Novartis. "When combined with the most recent financing commitment from the Global Fund, these results underpin our efforts to rapidly ramp up the production of Coartem."

Since 2001, Novartis has supplied more than six million treatments of artemether-lumefantrine on a non-profit basis for distribution to the public sector in malaria-endemic developing countries. Production of Coartem, currently the leading artemisinin-based combination therapy (ACT), has increased from 100,000 treatments in 2002 to a projected 30 million treatments in 2005. The original 2001 agreement between Novartis and the WHO forecast demand for Coartem at just over two million treatments in 2005. Since then, non-binding demand forecasts provided by WHO have continuously increased, including a six-fold jump in the 2005 demand forecast between December 2003 and March 2004. In this three month period, the WHO demand forecast surged from 10 million to 60 million treatments.

Published: Saturday 30 April 2005

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AJU GETS REAL TV SHOW ON REALSTARS ON STARTIMES

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Obama signs order to cut travel, cellphones, swag

WASHINGTON (AP) — With the stroke of his pen, President Barack Obama has sacked souvenirs federal agencies buy with taxpayer money to promote their work. The ban he signed Wednesday is part of a broader executive order to cut some $4 billion of dollars in waste and make government more efficient. Some office equipment will simply be scarcer, and fewer cell phones and laptops will be issued. Obama has been using his executive powers on modest proposals — Wednesday's order targets trinkets like coffee cups, T-shirts and pens — to promote job creation, help homeowners or, in this case, redirect spending. With such orders, signed in Oval Office ceremonies, Obama is trying to demonstrate that he is engaged in measures large and small and to distinguish himself from what he argues is a pretty unproductive Congress. Lawmakers are in the middle of a more gargantuan task — cutting deficits by at least $1.5 trillion over the next 10 years. "It doesn't replace the importance of work the Congress needs to do in coming up with a balanced, bold plan to reduce our deficit," Obama said as he prepared to sign his administrative order. "But it indicates once again that there are things that we can do right now that will actually deliver better government, more efficiently, more consumer friendly for less money." The saved money won't directly reduce deficits, however. In a statement in advance of the signing, Obama said, "We're cutting what we don't need so that we can invest in what we do need." An administration official said the savings of about $4 billion would allow the administration to focus resources on veterans, members of the military and on infrastructure. The order directs government agencies not only to reduce the authorizations for technology equipment, but also requires cutting the size of the executive vehicle fleet. It also encourages agencies to use technology to save money, including teleconferences and online seminars to reduce travel and online publishing to cut down on publication costs. Overall, the president aims to cut spending in the areas mentioned in the order by 20 percent. "We believe we can get better results for less using technology," Obama said. Vice President Joe Biden and White House budget director Jacob Lew attended the signing in the Oval Office. Obama was also accompanied by four finalists in a cost-saving contest among federal government employees. One finalist suggested the creation of a tool "lending library," another proposed ending the purchase of U.S. code books that are already available online. Among examples cited by the White House of cost-cutting already under way are the Internal Revenue Service's plan to cut 27 percent of its travel costs by relying more on teleconferences and webinars and the Homeland Security Department's decision to conduct annual audits to reduce the number of unused cellphones and air cards. At the Commerce Department, the White House said, the agency has reduced the number of fleet drivers to one for all top departmental officials, including for new Secretary John Bryson.

Heavy D dies at 44

LOS ANGELES (Reuters) - Rapper Heavy D, who rose to fame during the 1990s and scored hit singles such as "Now That We Found Love", died on Tuesday after collapsing outside his Beverly Hills home. He was 44. Beverly Hills Police Lt. Mark Rosen said in a statement that the rapper, whose real name is Dwight Arrington Meyers, was found on a walkway at 11:25 a.m. PST outside his condominium. He conscious and talking, but having difficulty breathing. Paramedics were called and the singer was rushed to a nearby hospital. "The individual ultimately died at the hospital," Rosen said. He added that there were no signs of foul play, and the death is believed to be medically related. An official cause is pending an autopsy by Los Angeles County coroners. The singer's New York-based agent was not immediately available for comment. Rotund rapper Heavy D was born in Jamaica and moved to Mt. Vernon, New York as a child. He enjoyed hip hop music as a kid and formed his first group, the Boyz, with high school friends who took the stage names DJ Eddie F, Trouble T-Roy and G-Wiz. The group became Heavy D & The Boyz and released their first album in 1987, which included singles "Mr. Big Stuff" and "The Overweight Lover's in the House." Their breakout album came with 1989's "Big Tyme," which included the hits "Somebody for Me" and "We Got Our Own Thang." The band met with tragedy in 1990 when Trouble T-Roy died in an accident. One year later, they scored their biggest hit with the album "Peaceful Journey" and single "Now That We Found Love," which reached the top five on R&B charts and crossed over to mainstream pop audiences. A string of hits followed in the 1990s. The band sang the theme song for popular TV show "In Living Color," and Heavy D's 1999 CD "Heavy" became his seventh album to chart among the R&B top 10. During those years, the rapper also began acting, working in small roles on film and TV before landing a role in high-school TV drama "Boston Public". His film work included parts in "The Cider House Rules," "Step Up" and "Big Trouble."

Eddie Murphy quits Oscars after Brett Ratner exit

Actor and comedian Eddie Murphy has resigned as host of the 2012 Oscar ceremony, due to be held in February. His decision comes a day after the resignation of producer Brett Ratner, a friend of Murphy, who used a derogatory term in public. Mr Ratner used the word "fags" during a question and answer session on his latest film Tower Heist. Mr Ratner recruited Murphy to be the Oscars' next host when he was hired as producer of the 2012 awards ceremony. The Rush Hour director has been replaced by Brian Grazer, the Oscar-winning producer of A Beautiful Mind - and frequent producing partner of director Ron Howard. "Brian Grazer is a renowned filmmaker who over the past 25 years has produced a diverse and extraordinary body of work," said Academy President Tom Sherak. "He will certainly bring his tremendous talent, creativity and relationships to the Oscars.' No replacement has been announced for Murphy. Ratings push Correspondents say the comedian's resignation could be a setback for the Academy Awards. The ceremony has seen declining TV ratings in recent years and is battling the rise of newer awards ceremonies, which appeal to younger audiences. Choosing Murphy to host for the 2012 ceremony marked a return to the traditional, well-tried formula of a comedian host - one very successful ceremony was hosted by Bob Hope, Johnny Carson and Billy Crystal. Oscar officials and Eddie Murphy himself insisted the split was not an acrimonious one. "I appreciate how Eddie feels about losing his creative partner, Brett Ratner, and we all wish him well," Sherak said of Murphy's decision to step down. Murphy said: "I was truly looking forward to being a part of the show that our production team and writers were just starting to develop, but I'm sure that the new production team and host will do an equally great job." An online campaign to replace Murphy with the Muppets was initiated on Wednesday.

Friday 8 January 2016

Coartem(reg) (artemether-lumefantrine) most effective malaria treatment in areas of high resistance to conventional anti-malarials

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